Publications

• Pharmacokinetic analysis of carboplatin and fluorescein brain retention following ultrasound-based blood-brain barrier opening.

Habashy KJ, Synold TW, Feng Y, Gomez C, Amidei C, Ward R, VanderMolen S, Zarrieneh A, Kim K-S, Gomez M, Arrieta VA, Fares J, Burdett KB, Zhang H, Dmello C, Chen L, Bebawy JF, Canney M, Stupp R, Badie B, Portnow J, Sonabend AM

Clin Cancer Res. 2025 Jun;

https://doi.org/10.1158/1078-0432.CCR-25-0080

PMID: 40495421

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• Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors.

Qian H, Ali H, Karri V, Low JT, Ashley DM, Heimberger AB, Godley LA, Sonabend AM, Dmello C

Oncotarget. 2025 Jun; 16: 445-453.

https://doi.org/10.18632/oncotarget.28740

PMID: 40492861

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• Rethinking metastatic brain cancer as a CNS disease.

Fares J, Petrosyan E, Dmello C, Lukas RV, Stupp R, Lesniak MS

Lancet Oncol. 2025 Feb; 26(2): e111-e121.

https://doi.org/10.1016/S1470-2045(24)00430-3

PMID: 39914421

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• Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy?

Du R, Zhang J, Lukas RV, Tripathi S, Ahrendsen JT, Curran MA, Dmello C, Zhang P, Stupp R, Rao G, Heimberger AB

Neuro Oncol. 2025 Jan; 27(1): 33-49.

https://doi.org/10.1093/neuonc/noae193

PMID: 39427326

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• Endothelial response to blood-brain barrier disruption in the human brain.

Gould A, Luan Y, Hou Y, Korobova FV, Chen L, Arrieta VA, Amidei C, Ward R, Gomez C, Castro B, Habashy K, Zhang D, Youngblood M, Dmello C, Bebawy J, Bouchoux G, Stupp R, Canney M, Yue F, Iruela-Arispe ML, Sonabend AM

JCI Insight. 2024 Dec; 10(4):

https://doi.org/10.1172/jci.insight.187328

PMID: 39724015

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• Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas.

Kim K-S, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L, Zhang DY, Castro B, Billingham L, Levey D, Huber O, Marques M, Savitsky DA, Morin BM, Muzzio M, Canney M, Horbinski C, Zhang P, Miska J, Padney S, Zhang B, Rabadan R, Phillips JJ, Butowski N, Heimberger AB, Hu J, Stupp R, Chand D, Lee-Chang C, Sonabend AM Neuro Oncol. 2024 Nov; 26(11): 2044-2060.

https://doi.org/10.1093/neuonc/noae135

PMID: 39028616

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• MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy.

Kim K-S, Zhang J, Arrieta VA, Dmello C, Grabis E, Habashy K, Duffy J, Zhao J, Gould A, Chen L, Hu J, Balyasnikova I, Chand D, Levey D, Canoll P, Zhao W, Sims PA, Rabadan R, Pandey S, Zhang B, Lee-Chang C, Heiland DH, Sonabend AM

bioRxiv. 2024 Sep;

https://doi.org/10.1101/2024.09.11.612571

PMID: 39345374

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• THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression.

Budhiraja S, Baisiwala S, Cho S, Chojak R, Kazi HA, Stepniak A, Perrault EN, Chen L, Park CH, Dmello C, Lin P, Sonabend AM, Ahmed AU

bioRxiv. 2024 Sep;

https://doi.org/10.1101/2024.09.24.614748

PMID: 39386597

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• Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas.

Arrieta VA, Gould A, Kim K-S, Habashy KJ, Dmello C, Vázquez-Cervantes GI, Palacín-Aliana I, McManus G, Amidei C, Gomez C, Dhiantravan S, Chen L, Zhang DY, Saganty R, Cholak ME, Pandey S, McCord M, McCortney K, Castro B, Ward R, Muzzio M, Bouchoux G, Desseaux C, Canney M, Carpentier A, Zhang B, Miska JM, Lesniak MS, Horbinski CM, Lukas RV, Stupp R, Lee-Chang C, Sonabend AM

Nat Commun. 2024 Jun; 15(1): 4698-.

https://doi.org/10.1038/s41467-024-48326-w

PMID: 38844770

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• STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma.

Najem H, Lea ST, Tripathi S, Hurley L, Chen C-H, William I, Sooreshjani M, Bowie M, Hartley G, Dussold C, Pacheco S, Dmello C, Lee-Chang C, McCortney K, Steffens A, Walshon J, Ott M, Wei J, Marisetty A, Balyasnikova I, Stupp R, Lukas RV, Hu J, James CD, Horbinski CM, Lesniak MS, Ashley DM, Priebe W, Platanias LC, Curran MA, Heimberger AB

J Clin Invest. 2024 Jun; 134(12):

https://doi.org/10.1172/JCI175033

PMID: 38941297

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• Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma.

Habashy KJ, Dmello C, Chen L, Arrieta VA, Kim K-S, Gould A, Youngblood MW, Bouchoux G, Burdett KB, Zhang H, Canney M, Stupp R, Sonabend AM

Clin Cancer Res. 2024 Apr; 30(8): 1619-1629.

https://doi.org/10.1158/1078-0432.CCR-23-2367

PMID: 38295144

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• Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications.

Onkar A, Khan F, Goenka A, Rajendran RL, Dmello C, Hong CM, Mubin N, Gangadaran P, Ahn B-C

ACS Appl Mater Interfaces. 2024 Feb; 16(6): 6709-6742.

https://doi.org/10.1021/acsami.3c16839

PMID: 38315446

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• Combining causal and correlative approaches to discover biomarkers of response to paclitaxel.

Moscona-Nissan A, Habashy KJ, Arrieta VA, Sonabend AM, Dmello C

Oncotarget. 2024 Feb; 15: 117-122.

https://doi.org/10.18632/oncotarget.28549

PMID: 38329732

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• Phase II trial of blood-brain barrier permeable peptide-paclitaxel conjugate ANG1005 in patients with recurrent high-grade glioma.

Dmello C, Brenner A, Piccioni D, Wen PY, Drappatz J, Mrugala M, Lewis LD, Schiff D, Fadul CE, Chamberlain M, Kesari S, Ahluwalia M, Ghosh D, Sonabend AM, Kumthekar P

Neurooncol Adv. 2024; 6(1): vdae186-.

https://doi.org/10.1093/noajnl/vdae186

PMID: 39713041

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• ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis.

Arrieta VA, Duerinck J, Burdett KB, Habashy KJ, Geens W, Gould A, Schwarze JK, Dmello C, Kim K-S, Saganty R, Chen L, Moscona A, McCord M, Lee-Chang C, Horbinski CM, Zhang H, Stupp R, Neyns B, Sonabend AM

Clin Cancer Res. 2024 Jan; 30(2): 379-388.

https://doi.org/10.1158/1078-0432.CCR-23-1889

PMID: 37939133

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• Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.

Rashidi A, Billingham LK, Zolp A, Chia T-Y, Silvers C, Katz JL, Park CH, Delay S, Boland L, Geng Y, Markwell SM, Dmello C, Arrieta VA, Zilinger K, Jacob IM, Lopez-Rosas A, Hou D, Castro B, Steffens AM, McCortney K, Walshon JP, Flowers MS, Lin H, Wang H, Zhao J, Sonabend A, Zhang P, Ahmed AU, Brat DJ, Heiland DH, Lee-Chang C, Lesniak MS, Chandel NS, Miska J

Cell Metab. 2024 Jan; 36(1): 62-77.e8.

https://doi.org/10.1016/j.cmet.2023.11.013

PMID: 38134929

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